A REVIEW OF CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most lately, it's been identified that conolidine and the above derivatives act on the atypical chemokine receptor three (ACKR3. Expressed in similar spots as classical opioid receptors, it binds to the big range of endogenous opioids. Unlike most opioid receptors, this receptor acts for a scavenger and doesn't activate a next messenger program (59